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Thermal Analysis (DSC, XRPD and TAM)
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Fig. 1. Fast scan Diffrential Scanning Calorimetry(Perkin Elmer
Diamond DSC)
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Fast scan DSC, is used for solid-state characterization, i.e.
determination of glass transition temperature (Tg) and crystallization temperature (Tc) in amorphous materials and determination
of melting temp (Tm) of crystalline/ partially crystalline samples.
In the example below, determination of Tg by
Diamond DSC is shown.
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Fig.2. Determination of Tg by Diamond DSC.
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Fig 3. Seiko DSC
Seiko DSC is used at HTD Biosystems for
both solid-state characterization and also for determination of denaturation temperature of proteins in liquid formulations
at high concentrations (>10 mg/ml).
In addition to DSC, HTD Biosystems provides experties in other thermal analysis
methods such as Isothermal Microcalorimetry (IMC), TAM (Thermal Activity Monitor) and Isothermal Titration Microcalorimetry
(ITC). Microcalorimetry can be used for determination of degree of solid-state disorder (amorphicity) of pharmaceutical drugs,
when degree of amorphicity is very small (even 1%).
Isothermal Titration Microcalorimetry can be used to study complexation
reactions such as protein-ligand interactions.
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