Differential Scanning Calorimetry (DSC)

Cold-Stage DSC/ Determination of Tg'

Thermal analysis in the solid-state DSC is used for determination of glass transition temperature (Tg), crystallization temperature (Tc) and melting temperature (Tm) of solids.  At HTD, we usually utilize this technique for determination of amorphicity of lyophilized cakes of proteins. We have also used it for determination of amorphicity in polymers. In the example below, determination of Tg of Trehalose at 100 oC/min, by Diamond DSC is shown.

Figure.1. Determination of Tg by Diamond DSC.