Differential Scanning CalorimetryDSC is used for determination of solid-state structure of powders, polymer films, and lyophilized cakes. Thermal stability of the solid is investigated by measuring Tg, Tc, Tm, and ∆H. for a review of different applications of solid-state DSC see our application note for DSC. DSC can also be used to measure Tg' and Tc in a frozen liquid. Such information is important for freeze-drying cycle development.